Kau Lab publications
The gut microbiota shapes the human and murine breath volatilome
Ariel J. Hernandez-Leyva, Amalia Z. Berna, Maggie H. Bui, Yang Liu, Anne L. Rosen, Michael A. Lint, Samantha A. Whiteside, Natalia Jaeger, Ryan T. McDonough, Nikhilesh Joardar, Jesús Santiago-Borges, Christopher P. Tomera, Wentai Luo, Audrey R. Odom John*, Andrew L. Kau*
Cell Metabolism, January 2026
Uropathogenic Escherichia coli niche occupancy determines the effects of mucosal vaccine against FimH
Jesús M. Santiago-Borges, Anne L. Rosen, Ariel Hernandez-Leyva, Christopher P. Tomera, Michael A. Lint, Alexandra E. Paharik, Vincent Vanyo, Jerome S. Pinkner, Karen W. Dodson, Swaine L. Chen, Chyi S. Hsieh, Scott J. Hultgren, Andrew L. Kau*
Cell Reports, August 2025
Monoclonals antibodies targeting the fimh adhesin protect against uropathogenic e. coli uti
Edward D B Lopatto#, Jesús Santiago-Borges#, Denise A. Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W. Timm, Isabella F. Fox, Nathaniel C. Gualberto, Jerome S. Pinkner, Karen W. Dodson, Ali H. Ellebedy*, Andrew L. Kau*, Scott J. Hultgren*
Scientific Advances, June 2025
Upper and lower airway microbiota across infancy and childhood
Ariel Hernandez-Leyva, Anne L. Rosen, Christopher P. Tomera, Elaina E. Lin, Elikplim H. Akaho, Allison M. Blatz, William R. Otto, Joey Logan, Lisa R. Young, Rebecca M. Harris, Samantha A. Whiteside, Andrew L. Kau*, Audrey R. Odom John*
Pediatric Research, February 2025
The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma
Naomi G. Wilson, Ariel Hernandez-Leyva, Drew J. Schwartz, Leonard B. Bacharier, Andrew L. Kau*
FEMS Microbes, March 2024
Secretory leukocyte protease inhibitor protects against severe urinary tract infection
Anne L. Rosen, Michael A. Lint, Dayne H. Voelker, Nicole M. Gilbert, Christopher P. Tomera, Jesús Santiago-Borges, Meghan A. Wallace, Thomas J. Hannan, Carey-Ann D. Burnham, Scott J. Hultgren, Andrew L. Kau*
mBio, January 2024
The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice
Naomi G. Wilson#, Ariel Hernandez-Leyva#, Anne L. Rosen, Natalia Jaeger, Ryan T. McDonough, Jesus Santiago-Borges, Michael A. Lint, Thomas R. Rosen, Christopher P. Tomera, Leonard B. Bacharier, S. Joshua Swamidass, Andrew L. Kau*
iScience, January 2023
Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation
Natalia Jaeger, Ryan T. McDonough, Anne L. Rosen, Ariel Hernandez-Leyva, Naomi G. Wilson, Michael A. Lint, Emilie V. Russler-Germain, Jiani N. Chai, Leonard B. Bacharier, Chyi-song Hseih, Andrew L. Kau*
Cell Reports, November 2020
Journal Covers
To Catch Breath by Lingwei Lyu
The cover art depicts a child imagining floating in the clouds while blowing bubbles. The bubbles are filled with bacteria and volatile organic compounds reflecting the relationship between the gut microbiome and exhaled breath volatilome described in Hernandez-Leyva et al. The artwork’s style is inspired by children’s picture books in dedication to the kids that helped make the study possible.
Submitted
Reviews
Can Therapeutic Targeting of the Human Microbiome Influence Asthma Management? A Pro/Con Debate
Andrew L. Kau, Anne L. Rosen, Christian Rosas-Salazar
Journal of Allergy and Clinical Immunology: In Practice, January 2024
The Abcs of wheeze: asthma and bacterial communities
Naomi G. Wilson, Ariel Hernandez-Leyva, Andrew L. Kau
PLoS Pathogen, April 2019
Breathe soft, through early windows break
Ariel Hernandez-Leyva, Naomi G. Wilson, Andrew L. Kau
Cell Host and Microbe, September 2018
Collaborations
A hierarchy of intestinal antigens instructs the CD4+ T cell receptor repertoire
Jaeu Yi, Jisun Jung, David Horton, Patricia Hsieh, Yangqing Peng, Sean J. Wang, Rodney Newberry, Aaron C. Ericsson, Kwang Soon Kim, Andrew L. Kau, Chyi-Song Hsieh
Immunity, 2025
Mechanisms of uropathogenic E. coli mucosal association in the gastrointestinal tract
Philippe N. Azimzadeh, George M. Birchenough, Nathaniel C. Gualberto, Jerome S. Pinkner, Kevin O. Tamadonfar, Wandy Beatty, Thomas J. Hannan, Karen W. Dodson, Enid C. Ibarra, Seonyoung Kim, Henry L. Schreiber, James W. Janetka, Andrew L. Kau, Ashlee M. Earl, Mark J. Miller, Gunnar C. Hansson, Scott J. Hultgren
gut microbiota and microbiota-derived metabolites promotes endometriosis
Sangappa B. Chadchan, Sumanta K. Naik, Pooja Popli, Chandni Talwar, Satwikreddy Putluri, Chandrasekhar R. Ambati, Michael A. Lint, Andrew L. Kau, Christina L. Stallings, Ramakrishna Kommagani
Cell Death Discovery, 2023
Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses
Guy Hazan, Anna Eubanks, Carrie Gierasch, Jeffrey Atkinson, Carolyn Fox, Ariel Hernandez-Leyva, Anne L. Rosen, Andrew L. Kau, Eugene Agapov, Jennifer Alexander-Brett, Deborah Steinberg, Diane Kelley, Michael White, Derek Byers, Kangyun Wu, Shamus P. Keeler, Yong Zhang, Jeffrey R. Koenitzer, Elise Eiden, Neil Anderson, Michael J. Holtzman, Jeffrey Haspel
Journal of Immunology, 2022
Altered IgA Response to Gut Bacteria Is Associated with Childhood Asthma in Peru
Chyi-Song Hsieh, Sunaina Rengarajan, Andrew L. Kau, Carla Tarazona-Meza, Andrew Nicholson, William Checkley, Karina Romero, Nadia N. Hansel
Journal of Immunology, 2021
Previous Works
Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice
Planer JD, Peng Y, Kau AL, Blanton LV, Ndao IM, Tarr PI, Warner BB, Gordon JI
Nature, 2016
Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy
Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, Manary MJ, Liu TC, Stappenbeck TS, Maleta KM, Ashorn P, Dewey KG, Houpt ER, Hsieh CS, Gordon JI
Science Translational Medicine, 2015
Human nutrition, the gut microbiome and the immune system
Kau AL*, Ahern PP*, Griffin NW, Goodman AL, Gordon JI
Nature, 2011
Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice
Kau AL, Martin SM, Lyon W, Hayes E, Caparon MG, Hultgren SJ
Infection and Immunity, 2005
Interaction of uropathogenic Escherichia coli with host uroepithelium
Kau AL, Hunstad DA, Hultgren SJ
Current Opinion in Microbiology, 2005